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Polydrug use, or the use of more than one medication or illicit substance at a time, is fraught with risks and concerns. Depending on the substances used, the effects will vary, but when someone uses both an opiate drug, such as painkillers like OxyContin or heroin, and a benzodiazepine like Xanax , the result can be deadly. RISKS OF COMBINING BENZOS AND OPIATES Use of benzodiazepines in combination with opiate drugs creates a synergistic effect in the body. This means that rather than experiencing the effect of benzodiazepines plus the effect of the opiate drug, the user experiences a far more amplified effect of both substances in combination. In other words, one plus one does not equal two in this instance. buy Adderall XR 30 mg online without prescription The results of this combination, especially when one is new to drug use or when one drug is more potent than expected, can be life-altering, if not life-ending. A few of the risks associated with the use of benzos in combination